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KMID : 1155520060010010048
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Anesthesia and Pain Medicine
2006 Volume.1 No. 1 p.48 ~ p.52
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The Maternal and Neonatal Effect of Remifentanil in General Anesthesia for Cesarean Section
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Lee Eui-Min
Kim Dong-Yeon
Chung Rack-Kyung
Lee Guie-Yong
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Abstract
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Background: In case of general anesthesia for cesarean section, giving remifentanil has been described, but its maternal and neonatal effects and safety have not been investigated by a controlled study.
Methods: 20 healthy women undergoing elective cesarean section under general anesthesia at term were allocated randomly to receive remifentanil as effect site concentration of 3.0 ng/ml (R group, n = 10) and same amount of normal saline (C group, n = 10) just before endotracheal intubation. Each group was assessed for bispectral index (BIS), blood pressure, and heart rate at preinduction, arrival to target concentration, intubation, and 1 and 3 minutes after intubation and delivery. Neonatal effect was assessed by Apgar score at 1 and 5 minutes.
Results: The BIS of remifentanil group was lower than that of control group at 1 min after intubation (P ＜ 0.05). The systolic blood pressure of remifentanil group were lower than those of control group at immediately after intubation (P ＜ 0.05) and 1 min after intubation (P ＜ 0.01). There were no significant differences in heart rate between two groups.
Conclusions: We found that infusing remifentanil just before tracheal intubation was effective and safe to both mother and neonate. (Anesth Pain Med 2006; 1: 48∼52)
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KEYWORD
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cesarean section, general anesthesia, remifentanil
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